HomeRegisterLog inFollow us on facebookFollow us on twitterFollow us on youtubeFollow us on LinkedinFollow us on PintrestContact usFeedback

Share  | 

 Utilization of topiramate during pregnancy and risk of birth defects

View previous topic View next topic Go down 

PostSubject: Utilization of topiramate during pregnancy and risk of birth defects    Wed Jul 18, 2012 7:49 pm

Utilization of topiramate during pregnancy and risk of birth defects
Headache: The Journal of Head and Face Pain, 07/12/2012 Clinical Article

Green MW et al. – This retrospective study quantified the association between topiramate exposure during pregnancy and the risk of oral cleft or major congenital malformations, and suggested little or no increase in risk in comparison with exposure to other anti–epileptic drugs or to disease states, such as migraine, epilepsy, or diabetes. However, small numbers of events limit the strength of inferences.

•Sourced from patients' pharmacy and medical claims from 2002 through 2010, this study identified infants born from mothers exposed to topiramate (n = 870) and other anti–epileptic drugs (n = 3615) in the first trimester of pregnancy.
•First trimester exposure was based on prescription dispensing dates and days supplied relative to infant birth date, accounting for premature delivery.
•Infants born to women with migraine without epilepsy (n = 26,865), women with epilepsy (n = 2607), and women with diabetes mellitus (n = 13,062), as well as randomly sampled women (n = 99,761), were used for comparison.
•Topiramate use was excluded from all groups with the exception of the topiramate and random sample cohorts.
•Non–anti–epileptic drug teratogens were excluded from each cohort (except random sample).
•Unadjusted relative risks and 95% confidence intervals for topiramate vs each comparator were calculated.
•Risks >1 indicate a higher risk with topiramate vs comparator, whereas risks <1 indicate a lower risk with topiramate vs comparator.

•The frequency of oral clefts was 0.23% for topiramate use, 0.17% for other anti–epileptic drug use (topiramate vs comparator relative risk = 1.39 [95% confidence interval: 0.28–6.85]), 0.16% for migraineurs (1.47 [0.36–6.06]), 0.31% for epileptics (0.75 [0.16–3.52]), 0.26% for diabetics (0.88 [0.21–3.67]), and 0.16% for the random sample (1.44 [0.36–5.81]).
•The frequency of major congenital malformations was 4.33% for topiramate use, 3.21% for other anti–epileptic drugs (1.33 [0.92–1.90]), 3.79% for migraineurs (1.12 [0.81–1.55]), 4.33% for epileptics (0.98 [0.68–1.41]), 6.58% for diabetics (0.65 [0.47–0.89]), and 3.77% for the random sample (1.13 [0.82–1.55]).

Back to top Go down

Utilization of topiramate during pregnancy and risk of birth defects

View previous topic View next topic Back to top 

 Similar topics

Page 1 of 1

Permissions in this forum:You cannot reply to topics in this forum
www.ihaveiih.com :: Recommendations For You ::   :: Articles-
Jump to:  
DISCLAIMER This group is not managed by anyone in the medical profession, but by people who are either affected by, or are closely connected to IIH. Information provided on this site is meant to complement & not replace any advice or information from a health professional, users and members are reminded that medical professionals should always be consulted in all aspects of health needs.
Protected by Copyscape Web Copyright Protection Software
Top Disability Websites
Private forum on Forumotion | © phpBB | Free forum support | Contact | Report an abuse | Free forum